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PLC β3 Antibody (H-84): sc-13958

 |  Datasheet

(Based on data analysis)

  • PLC β3 Antibody (H-84) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 1151-1234 mapping at the C-terminus of PLC β3 of human origin
  • recommended for detection of PLC β3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • See 6 citations for PLC β3 Antibody (H-84)
 

See additional PLC Antibodies including PLC, PLC beta 1, PLC delta 1, PLC epsilon, PLC eta 1, PLC gamma 1, PLC zeta, PLC-L, PLC-XD1, PLC beta 2, PLC epsilon 2, PLC eta 2, PLC gamma 2, PLC beta 3, PLC delta 3, PLC beta 4 and PLC delta 4.

Also see PLC Inhibitors, PLC Activators or PLC Substrates for functional analysis of cellular responses to PLC.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   IHC(P)   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
PLC β3 Antibody (H-84) sc-13958 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PLC β3 siRNA (h) sc-36272 10 µM $258
PLC β3 siRNA (m) sc-36273 10 µM $258
PLC β3 siRNA (h2) sc-44321 10 µM $258
PLC β3 siRNA (r) sc-156124 10 µM $258
PLC β3 (h)-PR sc-36272-PR 10 µM, 20 µl $23
PLC β3 (m)-PR sc-36273-PR 10 µM, 20 µl $23
PLC β3 (h2)-PR sc-44321-PR 10 µM, 20 µl $23
PLC β3 (r)-PR sc-156124-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PLC β3 shRNA Plasmid (h) sc-36272-SH 20 µg $520
PLC β3 shRNA Plasmid (m) sc-36273-SH 20 µg $520
PLC β3 shRNA Plasmid (h2) sc-44321-SH 20 µg $520
PLC β3 shRNA Plasmid (r) sc-156124-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
PLC β3 shRNA (h) Lentiviral Particles sc-36272-V 200 µl $625
PLC β3 shRNA (m) Lentiviral Particles sc-36273-V 200 µl $625
PLC β3 shRNA (h2) Lentiviral Particles sc-44321-V 200 µl $625
PLC β3 shRNA (r) Lentiviral Particles sc-156124-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
MCF7 Whole Cell Lysate sc-2206 500 µg/200 µl $104
U-937 Cell Lysate sc-2239 500 µg/200 µl $104
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
KNRK Whole Cell Lysate sc-2214 500 µg/200 µl $104
COLO 320DM Cell Lysate sc-2226 500 µg/200 µl $104
PLC β3 (m): 293T Lysate sc-122623 100 µg/200 µl $205
PLC β3 (h): 293T Lysate sc-112691 100 µg/200 µl $205
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PLCB3 5331 11q13.1 NM_000932 Q01970
 600230
Mouse Plcb3 18797 19 A P51432
 N/A
 

Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1, 4, 5-triphosphate and diacylglycerol from phosphatidylinositol 4, 5 bisphosphate. A total of eight mammalian PLC isozymes have been described (PLC ∫1, PLC ∫2, PLC ∫3, PLC ∫4, PLC ©1, PLC ©2, PLC ∂1 and PLC ∂2). The ©-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two ©-type enzymes, but not the ∫ and ∂ isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC ∫1, PLC ∫2 and PLC ∫3 is mediated by the a subunits of the Gq class of heterotrimeric G proteins and by certain bg G protein subunits. The regulatory mechanisms for PLC ∂1 and PLC ∂2 are not yet resolved.

PLC β3 Antibody (H-84) Product Citations
See how others have used PLC β3 Antibody (H-84) and or PLC β3 Antibody (H-84) conjugates.


6 total citations
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PLC β3 Antibody (H-84) Data
Click on image to enlarge
sc-13958
PLC β3 (H-84): sc-13958. Western blot analysis of PLC β3 expression in A-431 (A), MCF7 (B), U-937 (C), NIH/3T3 (D) and KNRK (E) whole cell lysates.
sc-13958
PLC β3 (H-84): sc-13958. Immunoperoxidase staining of formalin fixed, paraffin-embedded human appendix tissue showing cytoplasmic and membrane staining of glandular cells and lymphoid tissue at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
sc-13958
PLC β3 (H-84): sc-13958. Western blot analysis of PLC β3 expression in non-transfected 293T: sc-117752 (A), human PLC β3 transfected 293T: sc-112691 (B) and A-431 (C) whole cell lysates.
sc-13958
PLC β3 (H-84): sc-13958. Western blot analysis of PLC β3 expression in non-transfected 293T: sc-117752 (A), mouse PLC β3 transfected 293T: sc-122623 (B) and KNRK (C) whole cell lysates.
sc-13958
PLC β3 (H-84): sc-13958. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
sc-13958
PLC β3 (H-84): sc-13958. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing cytoplasmic staining of glandular cells.
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