Welcome to Santa Cruz Biotechnology!

RICS Antibody (N-14): sc-139169

 |  Datasheet

(Based on data analysis)

  • RICS Antibody (N-14) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping near the N-terminus of RICS of human origin
  • recommended for detection of RICS of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including porcine
  • blocking peptide, sc-139169 P
 

See additional RICS Antibodies.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
RICS Antibody (N-14) sc-139169 200 µg/ml $279
RICS (N-14) P sc-139169 P
(peptide)
100 µg/0.5 ml $61
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RICS CRISPR/Cas9 KO Plasmid (h) sc-404510 20 µg $345
RICS HDR Plasmid (h) sc-404510-HDR 20 µg $385
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RICS siRNA (h) sc-96831 10 µM $258
RICS siRNA (m) sc-152958 10 µM $258
RICS (h)-PR sc-96831-PR 10 µM, 20 µl $23
RICS (m)-PR sc-152958-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RICS shRNA Plasmid (h) sc-96831-SH 20 µg $520
RICS shRNA Plasmid (m) sc-152958-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
RICS shRNA (h) Lentiviral Particles sc-96831-V 200 µl $625
RICS shRNA (m) Lentiviral Particles sc-152958-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human RICS 9743 11q24.3 NM_001142685, NM_014715 A7KAX9
608541
Mouse Grit 330914 9 A4 NM_177379 Q811P8
N/A
 


RICS, also known as GRIT, p200RhoGAP, p250GAP or GC-GAP, is a 2,087 amino acid protein that localizes to various regions within the cell, including the cell junction, the endosomal membrane and the endoplasmic reticulum, and contains one SH3 domain, one Rho-GAP domain and one PX domain. Existing as multiple alternatively spliced isoforms that are expressed in a tissue-specific manner, RICS functions as a GTPase-activating protein (GAP) that promotes GTP hydrolysis on a variety of target proteins and is thought to be involved in neuronal differentiation. Additionally, RICS is involved in Actin reorganization in dendritic spines and may participate in Rho- and Ras-regulated signaling pathways in cell growth regulation. Specific RICS isoforms are subject to in vitro phosphorylation, an event which inhibits GAP activity.