Snurportin-1 Antibody (B-12): sc-137133
- Snurportin-1 Antibody (B-12) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 11-43 at the N-terminus of Snurportin-1 of human origin
- recommended for detection of Snurportin-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Snurportin-1 Antibody (B-12) for WB applications. These reagents are now offered in bundles with Snurportin-1 Antibody (B-12) (see ordering information below).
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Snurportin-1 Antibody (B-12) is a mouse monoclonal IgG1 antibody that detects Snurportin-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Snurportin-1, also known as SNUPN, KPNBL, or RNUT1 (RNA U transporter 1), is a crucial nuclear import adaptor protein that plays a significant role in the transport of U small nuclear ribonucleoproteins (U snRNPs) into the nucleus, a vital step in the maturation of the spliceosome. This protein is characterized by its unique structure, which includes an N-terminal importin β-binding (IBB) domain and a trimethylguanosine (m3G)-cap binding domain, allowing Snurportin-1 to specifically recognize and bind the terminal 2,2,7-m3G-cap at the 5′ end of U snRNPs. The interaction between Snurportin-1, U snRNPs, and Importin β forms a complex that is essential for the nuclear import process. Once inside the nucleus, Snurportin-1 may localize to Cajal bodies, depending on the specific U snRNP involved, such as U1 or U2. Additionally, Snurportin-1 is recycled back to the cytoplasm by CRM1, ensuring continuous facilitation of multiple rounds of U snRNP import, thereby maintaining the efficiency of spliceosome assembly and function. Snurportin-1 (B-12) antibody is an invaluable tool for researchers studying RNA processing and spliceosome dynamics in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Snurportin-1 Antibody (B-12) | sc-137133 | 200 µg/ml | $322.00 | |||
Snurportin-1 Antibody (B-12): m-IgG Fc BP-HRP Bundle | sc-539942 | 200 µg Ab; 10 µg BP | $361.00 | |||
Snurportin-1 Antibody (B-12): m-IgG1 BP-HRP Bundle | sc-541801 | 200 µg Ab; 20 µg BP | $361.00 | |||
Snurportin-1 (B-12) Neutralizing Peptide | sc-137133 P | 100 µg/0.5 ml | $69.00 |