epitope mapping near the C-terminus of hnRNP U of human origin
recommended for detection of hnRNP U of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
hnRNP U Background Information RNA polymerase II transcripts are complexed with hnRNP (heterogeneous nuclear ribonucleoprotein) proteins, which are involved in several aspects of hnRNA maturation and transport. The hnRNP particle U (also designated SP120 and SAF-A for scaffold attachment factor) is an abundant nucleoplasmic phosphoprotein and the largest of the major hnRNP proteins. hnRNP U is specifically involved in pre-mRNA processing and is directly bound to both RNA and DNA. Specifically, hnRNP U has a high affinity to the SAR (scaffold attachment region) of DNA . hnRNP U also functions as an RNA polymerase elongation inhibitor by inhibiting TFIIH-mediated phosphorylation of the carboxy-terminal domain of Pol II. Identical to GRIP120, hnRNP U also associates with glucocorticoid receptors to inhibit glucocorticoid induction.
hnRNP U (C-15) Product Citations
See how others have used hnRNP U (C-15): sc-13663 antibody and or hnRNP U (C-15) antibody conjugates.
2 total citations
Loading citations.
hnRNP U (C-15)
Click on image to enlarge
hnRNP U (C-15): sc-13663. Western blot analysis of hnRNP U expression in K-562 (A) and Jurkat (B) nuclear extracts.
hnRNP U (C-15): sc-13663. Western blot analysis of hnRNP U expression in non-transfected: sc-117752 (A) and human hnRNP U transfected: sc-113957 (B) 293T whole cell lysates and K-562 nuclear extract (C).
hnRNP U (C-15): sc-13663. Western blot analysis of hnRNP U expression in non-transfected: sc-117752 (A) and human hnRNP U transfected: sc-170307 (B) 293T whole cell lysates.
