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p-NFκB p65 Antibody (27.Ser 536): sc-136548

 |  Datasheet

(Based on data analysis)
  • p-NFκB p65 Antibody (27.Ser 536) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • raised against a short amino acid sequence containing phosphorylated Ser 536 of NFκB p65 of human origin
  • recommended for detection of Ser 536 phosphorylated NFκB p65 of human origin by WB, IHC(P) and ELISA
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-136548 X, 200 µg/0.1 ml
 

See additional NF kappa B Antibodies including NF kappa B, NF kappa B p50, NF kappa B p52, NF kappa B p65 and NF kappa B p100.

Also see NF kappa B Inhibitors or NF kappa B Activators for functional analysis of cellular responses to NF kappa B.


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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-NFκB p65 Antibody (27.Ser 536) sc-136548 200 µg/ml $279
p-NFκB p65 Antibody (27.Ser 536) X sc-136548 X 200 µg/0.1 ml $279

Proteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NF˚B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp ˚B sequence in the immunoglobulin k light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NFkB is activated and NFkB is subsequently transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct proteins have been described, designated p105 and p100. The p105 precursor contains p50 at its N-terminus and a C-terminal region that when expressed as a separate molecule, designated pdI, binds to p50 and regulates its activity.The NFkB transcription factor is a protein complex consisting of a DNA binding subunit and an associated protein. The DNA binding subunit, also referred to as Rel A, is functionally related to c-Rel p75 and RelB p68. NF˚Bp65 is phosphorylated at Serine-311 as a response to protein kinase C zeta.
p-NFκB p65 Antibody (27.Ser 536) Data
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sc-136548
p-NFκB p65 (27.Ser 536): sc-136548. Immunoperox-idase staining of formalin fixed, paraffin-embedded human tonsil tissue showing nuclear staining of cells in germinal and non-germinal centers.
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