Welcome to Santa Cruz Biotechnology!

MEK kinase-3 Antibody (40): sc-136260

 |  Datasheet

(Based on data analysis)

  • MEK kinase-3 Antibody (40) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
  • recommended for detection of MEK kinase-3 of mouse, rat and human origin by WB and IF; also reactive with additional species, including canine
 

See additional MEK kinase Antibodies including MEK kinase, MEK kinase-1, MEK kinase-2, MEK kinase-3 and MEK kinase-4.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
MEK kinase-3 Antibody (40) sc-136260 50 µg/0.5 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
MEK kinase-3 siRNA (h) sc-39108 10 µM $258
MEK kinase-3 siRNA (m) sc-156010 10 µM $258
MEK kinase-3 (h)-PR sc-39108-PR 10 µM, 20 µl $23
MEK kinase-3 (m)-PR sc-156010-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
MEK kinase-3 shRNA Plasmid (h) sc-39108-SH 20 µg $520
MEK kinase-3 shRNA Plasmid (m) sc-156010-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
MEK kinase-3 shRNA (h) Lentiviral Particles sc-39108-V 200 µl $625
MEK kinase-3 shRNA (m) Lentiviral Particles sc-156010-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MAP3K3 4215 17q23.3 Q99759
602539
Mouse Map3k3 26406 11 E1 Q61084
N/A
 


Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4, ASK 1 (MEK kinase-5) and MAP3K6 (MEK kinase-6). MEK kinase-1 has been shown to phosphorylate MEK-1 via a Raf-independent pathway. Evidence suggests that MEK-3 is preferentially activated by MEK kinase-3 and that MEK-4 is activated by both MEK kinase-2 and MEK kinase-3. MEK kinase-4 has been shown to specifically activate the JNK pathway. ASK1 activates both MEK-4 and MEK-3/MEK-6 pathways.

MEK kinase-3 Antibody (40) Data
Click on image to enlarge
MEK kinase-3 (40): sc-136260. Western blot analysis of MEK kinase-3 expression in HeLa whole cell lysate.
Western blot analysis of MEK kinase-3 phosphorylation in non-transfected: sc-117752 (A,D), untreated mouse MEK kinase-3 transfected: sc-125599 (B,E) and lambda protein phosphatase (sc-200312A) treated mouse MEK kinase-3 transfected: sc-125599 (C,F) 293T whole cell lysates. Antibodies tested include p-MEK kinase-3 (Ser 337)-R: sc-28044-R (A,B,C) and MEK kinase-3 (40): sc-136260 (D,E,F).
Download