MCPyV large T-antigen Background Information Merkel cells are round neuroendocrine cells found in skin that have synaptic contacts with somatosensory afferents. Responsible for touch and pressure sensation, Merkel cells can turn malignant and form a rare but aggressive form of skin cancer known as Merkel cell carcinoma (MCC). Approximately 80% of MCC are caused by a newly-described polyomavirus called Merkel cell polyomavirus, also known as MCPyV or MCV, that expresses a large T antigen in tumor cells. Full-length MCPyV large T antigen is a 125 kDa nuclear protein but MCPyV T antigens obtained from tumors have natural truncating mutations resulting in variably-sized, smaller proteins. MCPyV large T-antigen (CM2B4) was raised against a peptide in exon 2 of the T antigen locus and is highly specific for MCPyV large T and 57kT isoforms but will not detect MCPyV small T antigen. While human MCPyV infection is widespread, MCPyV large T antigen is a specific marker for Merkel cell tumors.
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MCPyV large T-antigen (CM2B4)
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MCPyV large T-antigen (CM2B4): sc-136172. Western blot analysis of MCPyV large T-antigen expression in non-transfected (A) and gLT206 encoding wild type full length genomic T antigen transfected (B) 293T whole cell lysates. Kindly provided by Patrick S. Moore, MD, University of Pittsburgh Cancer Institute.
MCPyV large T-antigen (CM2B4): sc-136172. Immunofluorescence staining of formaldehyde-fixed UISO cells retrovirally transduced to express MCPyV T antigen. The T antigen shows diffuse nuclear localization. Kindly provided by Patrick S. Moore, MD and Masa Shuda, PhD, University of Pittsburgh Cancer Institute.
