XRCC4 Background Information DNA repair proteins are necessary for the maintenance of chromosome integrity and are involved in the elimination of premutagenic lesions from DNA. The DNA-repair proteins Rad51 and Rad52 are key components of the double-strand-break repair pathway. Rad51 and Rad52 are essential for mitotic and meiotic recombination, and Rad51 mutation in yeast and mammalian cells results in chromosome loss. Rad51 has been shown in separate studies to interact with breast cancer susceptibility gene products BRCA1 and BRCA2, suggesting that these proteins may function as essential cofactors in Rad51-dependent DNA repair. Rad52 has been shown to associate with the RPA complex, a complex involved in DNA replication, nucleotide excision repair and homologous recombination. An additional protein involved in the DSBR pathway has been identified as XRCC4. XRCC4 has been shown to restore DSBR activity as well as V(D)J recombination in cells with impaired DSBR and V(D)J recombination.
XRCC4 (4)
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XRCC4 (4): sc-136124. Western blot analysis of XRCC4 expression in HeLa whole cell lysate.
XRCC4 (4): sc-136124. Immunofluorescence staining of HeLa cells showing nuclear staining.
XRCC4 (4): sc-136124. Western blot analysis of XRCC4 expression in MOLT-4 whole cell lysate.
