santa cruz biotechnology, inc.
| |
|
 |
- mouse monoclonal IgG1, 50 µg/0.5 ml
- recommended for detection of X11α of mouse and rat origin by WB, IP, IF and IHC(P)
|
|
| |
Ordering Information
Recommended Support Products:
(click button of application of choice)
| |
| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Mouse |
Apba1 |
319924 |
19 B |
|
NP_796008
|
N/A |
| |
X11α Background Information
The ∫-Amyloid precursor protein (∫-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The ∫-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular ∫-APP and slowing ∫-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of ∫-APP. Multiple splice varitents of X11 have been identified, including X11å (also designated Mint 1), X11∫ (Mint 2) and X11© (Mint 3). |
|
|
X11α (23)
Click on image to enlarge
|
|
X11α (23): sc-136122. Western blot analysis of X11α expression in rat cerebrum tissue extract.
X11 (23): sc-136122. Immunoperoxidase staining of formalin-fixed, paraffin-embedded rat cerebrum tissue showing cytoplasmic localization.
X11α (23): sc-136122. Immunoperoxidase staining of formalin-fixed, paraffin-embedded rat cerebrum tissue.
|
|
Download
|
| |
