SLP-76 Antibody (8): sc-136070

SLP-76 Antibody (8) is a mouse monoclonal IgG1 antibody that detects SLP-76 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). SLP-76 plays a pivotal role in T cell receptor signaling and is essential for the activation and development of lymphocytes, making SLP-76 a critical component in the immune response. Located primarily in the cytoplasm of T cells, SLP-76 interacts with various signaling molecules, including the adapter protein GRB2 and phospholipase C gamma 1 (PLC γ1), facilitating the transmission of signals that lead to T cell activation. The presence of multiple SH2/SH3-binding domains within SLP-76 allows SLP-76 to serve as a scaffold for assembling signaling complexes, which is vital for the propagation of signals that culminate in cellular responses such as cytokine production. Understanding the function and interactions of SLP-76 is crucial for elucidating the mechanisms underlying T cell activation and the overall immune response, highlighting SLP-76′s importance in both basic research and potential therapeutic applications. Anti-SLP-76 antibody (8) is an invaluable tool for researchers investigating the intricacies of immune signaling pathways.

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SLP-76 Antibody (8) References:

1. The adapter proteins LAT and SLP-76 are required for T-cell activation.  |  Finco, TS., et al. 1999. Cold Spring Harb Symp Quant Biol. 64: 265-74. PMID: 11232295
2. Known and potential functions for the SLP-76 adapter protein in regulating T-cell activation and development.  |  Clements, JL. 2003. Immunol Rev. 191: 211-9. PMID: 12614362
3. SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.  |  Wang, H., et al. 2009. Proc Natl Acad Sci U S A. 106: 12436-41. PMID: 19617540
4. The adapter protein SLP-76 mediates 'outside-in' integrin signaling and function in T cells.  |  Baker, RG., et al. 2009. Mol Cell Biol. 29: 5578-89. PMID: 19667077
5. SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.  |  Liu, H., et al. 2010. Proc Natl Acad Sci U S A. 107: 10166-71. PMID: 20534575
6. The adaptor protein SLP-76 regulates HIV-1 release and cell-to-cell transmission in T cells.  |  Nagaraja, T., et al. 2012. J Immunol. 188: 2769-77. PMID: 22323535
7. Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.  |  Coussens, NP., et al. 2013. Mol Cell Biol. 33: 4140-51. PMID: 23979596
8. Positive and negative regulation by SLP-76/ADAP and Pyk2 of chemokine-stimulated T-lymphocyte adhesion mediated by integrin α4β1.  |  Dios-Esponera, A., et al. 2015. Mol Biol Cell. 26: 3215-28. PMID: 26202465
9. Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells.  |  Xiong, Y., et al. 2019. J Immunol. 203: 3023-3036. PMID: 31666306
10. Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads.  |  Hallumi, E., et al. 2021. J Immunol. 206: 2322-2337. PMID: 33931484

The preferred SLP-76 antibody is SLP-76 Antibody (F-7): sc-13151.