p-p120 Background Information
The catenins, a, b and g, are proteins which bind to the highly conserved, intra-cellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. A related protein, p120 [catenin (cadherin associated protein), delta 1], also known as cadherin-associated Src substrate, Ctnnd1, Catns or Ctnnd, is a 968 amino acid tyrosine kinase substrate belonging to the beta-catenin family. Expressed in vascular endothelium, p120 localizes to the cytoplasm, nucleus and cell membrane. p120 plays a role in ligand-induced receptor signaling through EGF, PDGF, CSF-1 and Neu receptors, and exhibits sequence homology with the catenins at four discreet domains. p120 serves as a substrate for Src and is found in E-cadherin complexes containing catenins. p120 has four major isoforms, each of which has additional isoforms due to alternative splicing events. p120 contains ten ARM repeats and is phosphorylated following translation.
