C-Nap1 Background Information C-Nap1 (centrosome-associated protein), also known as Centrosomal Nek2-associated protein 1 or CEP2 (centrosomal protein 2), is localized to the cytoplasm and exists in every human cell. C-Nap1 is expressed as three isoforms and is a 2,442 amino acid protein. C-Nap1 is a centrosomal protein found at the tips of parental centrioles and in basal bodies of cellular projections, such as cillia. C-Nap1 is associated with the interphase stage of the cell cycle, during which C-Nap1 functions in the cohesion of centrioles. The phosphorylation of C-Nap1 plays a role in regulating whether the centrosomes are associating or dissociating. Nek2 phosphorylates the C-terminal end of C-Nap1 during mitosis, an event which is thought to play a role in the dissociation of centrosomes. C-Nap1 reacumulates in centrosomes at the end of cellular division. Some autoimmune diseases are characterized by the production of antibodies against C-Nap1, suggesting that C-Nap1 may be involved in the pathogenesis of autoimmune diseases.
C-Nap1 (42)
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C-Nap1 (42): sc-135851. Western blot analysis of C-Nap1 expression in Jurkat whole cell lysate.
C-Nap1 (42): sc-135851. Immunofluorescence staining of HeLa cells showing cytoplasmic localization.
