ARF3 Antibody (41): sc-135841

ARF3 Antibody (41) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARF3 protein of mouse, rat, human, and canine origin by western blotting (WB) and immunoprecipitation (IP). Anti-ARF3 antibody (41) is available in both non-conjugated and various conjugated forms, including horseradish peroxidase (HRP), providing flexibility for different experimental needs. ADP-ribosylation factor 3 (ARF3) is a crucial member of the ARF protein family, which is part of the Ras superfamily of regulatory GTP-binding proteins. This 181 amino acid protein is primarily localized to the Golgi apparatus, where ARF3 plays a vital role in vesicle trafficking and signal transduction within eukaryotic cells. Proper functioning of ARF3 is essential for maintaining organelle integrity, as ARF3 is involved in the assembly of coat proteins and the activation of phospholipase D, which are critical for membrane dynamics and cellular communication. ARF3 interacts with specific proteins such as PICK1, which may influence the budding and uncoating of vesicles in the Golgi apparatus, thereby impacting the overall efficiency of intracellular transport processes. ARF3 is known to activate cholera toxin and is mapped to human chromosome 12q13.12, highlighting ARF3′s significance in both cellular function and potential implications in disease mechanisms.

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ARF3 Antibody (41) References:

1. A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi.  |  Boman, AL., et al. 2000. Mol Biol Cell. 11: 1241-55. PMID: 10749927
2. Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3.  |  Irobi, J., et al. 2002. J Peripher Nerv Syst. 7: 87-95. PMID: 12090300
3. Heregulin promotes expression and subcellular redistribution of ADP-ribosylation factor 3.  |  Li, F., et al. 2002. FEBS Lett. 524: 49-53. PMID: 12135740
4. Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor.  |  Renault, L., et al. 2003. Nature. 426: 525-30. PMID: 14654833
5. Isolation and characterization of the human gene for ADP-ribosylation factor 3, a 20-kDa guanine nucleotide-binding protein activator of cholera toxin.  |  Tsai, SC., et al. 1991. J Biol Chem. 266: 23053-9. PMID: 1744102
6. circ_ARF3 regulates the pathogenesis of osteosarcoma by sponging miR-1299 to maintain CDK6 expression.  |  Gao, AM., et al. 2020. Cell Signal. 72: 109622. PMID: 32240746
7. ARF3 inhibits proliferation and promotes apoptosis in gastric cancer by regulating AKT and ERK pathway.  |  Liu, J., et al. 2021. Acta Biochim Pol. 68: 223-229. PMID: 33847108
8. De novo ARF3 variants cause neurodevelopmental disorder with brain abnormality.  |  Sakamoto, M., et al. 2021. Hum Mol Genet. 31: 69-81. PMID: 34346499
9. ARF3 weights the balance for prostate cancer metastasis.  |  Caswell, PT. 2023. J Cell Biol. 222: PMID: 36920439
10. ARF3-Mediated Regulation of SPL in Early Anther Morphogenesis: Maintaining Precise Spatial Distribution and Expression Level.  |  Yang, Q., et al. 2023. Int J Mol Sci. 24: PMID: 37511499
11. Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively.  |  Hirai, M., et al. 1996. Genomics. 34: 263-5. PMID: 8661066
12. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6).  |  Hosaka, M., et al. 1996. J Biochem. 120: 813-9. PMID: 8947846

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ARF3 Antibody (41) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-ARF3 Antibody (41) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ARF3 Antibody (41) Specifications

Alternate Product Name: ARF3

Product Clone Name: 41

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-181

Epitope Target: ARF3

Epitope Species: human

Product Reactivity/Detection: ARF3

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for ARF3 Antibody (41): AC: Agarose, HRP: Horseradish Peroxidase