BLM Antibody (BFL103): sc-13584
- BLM Antibody (BFL103) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against full length BLM (Bloom's Syndrome Protein) of human origin
- recommended for detection of BLM of human origin by WB, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for BLM Antibody (BFL103) for WB applications. These reagents are now offered in bundles with BLM Antibody (BFL103) (see ordering information below).
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BLM Antibody (BFL103) is a mouse monoclonal IgG1 antibody that detects BLM in human samples through applications such as western blotting (WB), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BLM, or Bloom′s syndrome protein, plays a crucial role in maintaining genomic stability by unwinding DNA during replication and repair processes, which is vital for preventing mutations that can lead to cancer. BLM is primarily located in the nucleus, where BLM interacts with both single- and double-stranded DNA, and BLM′s ATPase activity is essential for its helicase function. Mutations in the BLM gene result in a failure to properly unwind DNA, leading to an increased frequency of sister chromatid exchanges, a hallmark of Bloom′s syndrome. This dysfunction not only contributes to the characteristic growth deficiencies and immunodeficiency seen in affected individuals but also heightens their susceptibility to various cancers. Anti-BLM antibody (BFL103) is an invaluable tool for researchers studying the molecular mechanisms underlying Bloom′s syndrome and the broader implications of DNA repair pathways in cancer biology.
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BLM Antibody (BFL103) References:
- Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes. | Walpita, D., et al. 1999. Proc Natl Acad Sci U S A. 96: 5622-7. PMID: 10318934
- The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair. | Langland, G., et al. 2001. J Biol Chem. 276: 30031-5. PMID: 11325959
- Bloom's syndrome protein response to ultraviolet-C radiation and hydroxyurea-mediated DNA synthesis inhibition. | Ababou, M., et al. 2002. Oncogene. 21: 2079-88. PMID: 11960380
- Bloom's syndrome: Why not premature aging?: A comparison of the BLM and WRN helicases. | de Renty, C. and Ellis, NA. 2017. Ageing Res Rev. 33: 36-51. PMID: 27238185
- USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM. | Wu, C., et al. 2021. Nucleic Acids Res. 49: 11224-11240. PMID: 34606619
- Phenotypic spectrum of BLM- and RMI1-related Bloom syndrome. | Gönenc, II., et al. 2022. Clin Genet. 101: 559-564. PMID: 35218564
- Discovery of a Novel Bloom's Syndrome Protein (BLM) Inhibitor Suppressing Growth and Metastasis of Prostate Cancer. | Ma, XY., et al. 2022. Int J Mol Sci. 23: PMID: 36499126
- BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution. | Tsukada, K., et al. 2024. Mol Cell. 84: 640-658.e10. PMID: 38266639
- Small molecules that disrupt RAD54-BLM interaction hamper tumor proliferation in colon cancer chemoresistance models. | Kaur, E., et al. 2024. J Clin Invest. 134: PMID: 38421735
- BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response. | Jiang, H., et al. 2024. Mol Cell. 84: 1684-1698.e9. PMID: 38593805
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BLM Antibody (BFL103) | sc-13584 | 200 µg/ml | $322.00 | |||
BLM Antibody (BFL103): m-IgG Fc BP-HRP Bundle | sc-538897 | 200 µg Ab; 10 µg BP | $361.00 | |||
BLM Antibody (BFL103): m-IgG1 BP-HRP Bundle | sc-541130 | 200 µg Ab; 20 µg BP | $361.00 |