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p-Vav Antibody (39.Tyr 174): sc-135787

 |  Datasheet

(Based on data analysis)
  • p-Vav Antibody (39.Tyr 174) is a mouse monoclonal IgG3 provided at 200 µg/ml
  • raised against a short amino acid sequence containing phosphorylated Tyr 174 Vav of human origin
  • recommended for detection of Tyr 174 phosphorylated Vav of human origin by WB and ELISA
 

See additional Vav Antibodies including Vav, Vav2 and Vav3.

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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-Vav Antibody (39.Tyr 174) sc-135787 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Vav siRNA (h) sc-29517 10 µM $258
Vav (h)-PR sc-29517-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
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Vav shRNA Plasmid (h) sc-29517-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
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Vav shRNA (h) Lentiviral Particles sc-29517-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
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Jurkat + pervanadate Cell Lysate sc-24716 500 µg/200 µl $104
Jurkat + PMA Cell Lysate sc-24718 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human VAV1 7409 19p13.3 P15498
 164875
 

Vav proteins are guanine nucleotide exchange factors for Rho family GTPases which activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. Vav proteins contain several protein binding domains which can link cell surface receptors to downstream signaling proteins. Vav3 is a Ros receptor protein tyrosine kinase (RPTK) interacting protein and has a broad tissue expression profile that is distinct from those of Vav and Vav2. Vav3 mediates RPTK signaling and regulates GTPase activity, its native and mutant forms are able to modulate cell morphology, and it has the potential to induce cell transformation. For example, Vav3 induces marked membrane ruffles and microspikes in NIH/3T3 cells. Vav works as a GDP/GTP exchange factor for Rac GTPases, thereby facilitating the transition of these proteins from the inactive (GDP-bound) into the active (GTP-bound) state. The stimulation of Vav exchange activity during cell signaling is mediated by tyrosine phosphorylation. The residue, Tyrosine 174, is phospho-rylated following the stimulation of mitogenic and antigenic receptors. This phosphorylation event is conserved in Vav2 and Vav3, the other two members of the Vav family.