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p-SMC1α Antibody (30.Ser 966): sc-135783

 |  Datasheet

(Based on data analysis)

  • p-SMC1α Antibody (30.Ser 966) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • raised against a short amino acid sequence containing phosphorylated Ser 966 of SMC1α of mouse origin
  • recommended for detection of Ser 966 phosphorylated SMC1α of mouse origin by WB, IP and ELISA
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-135783 X, 200 µg/0.1 ml
 

See additional SMC Antibodies including SMC, SMC1, SMC1 alpha, SMC1 beta, SMC2, SMC3, SMC4, SMC5, SMC6 and SMC7.

Ordering InformationGene Info
Recommended Support Products:
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WB   IP   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-SMC1α Antibody (30.Ser 966) sc-135783 200 µg/ml $279
p-SMC1α Antibody (30.Ser 966) X sc-135783 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SMC1α siRNA (m) sc-38386 10 µM $258
SMC1α siRNA (h) sc-38385 10 µM $258
SMC1α (m)-PR sc-38386-PR 10 µM, 20 µl $23
SMC1α (h)-PR sc-38385-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SMC1α shRNA Plasmid (m) sc-38386-SH 20 µg $520
SMC1α shRNA Plasmid (h) sc-38385-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SMC1α shRNA (m) Lentiviral Particles sc-38386-V 200 µl $625
SMC1α shRNA (h) Lentiviral Particles sc-38385-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
HeLa + UV Cell Lysate sc-2221 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human SMC1A 8243 Xp11.22 NM_006306 Q14683
 300590
Mouse Smc1a 24061 X F3 Q9CU62
 N/A
 

The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. The two distinct classes of SMC protein complexes are comprised of SMC1 (also designated SB1.8) with SMC3 (also designated HCAP for human chromosome-associated protein and Bamacan for the secreted proteoglycan), and SMC2 (also designated hCAP-E) with SMC4 (also designated hCAP-C). The SMC1/SMC3 complex is required for metaphase progression in mitotic cells and functions independently of the SMC2/SMC4 complex during the cell cycle. SMC1 is ubiqitiously expressed in various human tissues, including thymus, testis and colon. SMC1å phosphorylated on Ser 957 and 966 associates with chromatin during G1/S/G2 phases, but not during M-phase, suggesting that phosphorylation does not regulate cohesion function. However, phosphorylation of SMC1å on Ser 957 and 966 is required for S-phase checkpoint activation.

p-SMC1α Antibody (30.Ser 966) Data
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sc-135783
Western blot analysis of SMC1α phosphorylation in untreated (A,D), UV irradiated (B,E) and UV irradiated and lambda protein phosphatase (sc-200312A) treated (C,F) HeLa whole cell lysates. Antibodies tested include p-SMC1α (30.Ser 966): sc-135783 (A,B,C) and SMC1α (M-16): sc-30958 (D,E,F).
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