Welcome to Santa Cruz Biotechnology!
SCBT Home
Home » Signaling Intermediates » RKIP Antibodies » p-RKIP Antibody (77.Ser 153): sc-135778

p-RKIP Antibody (77.Ser 153): sc-135778

 |  Datasheet

(Based on data analysis)
  • p-RKIP Antibody (77.Ser 153) is a mouse monoclonal IgG2b provided at 200 µg/ml
  • raised against a short amino acid sequence containing phosphorylated Ser 153 of RKIP of human origin
  • recommended for detection of Ser 153 phosphorylated RKIP of human origin by WB and ELISA
 

See additional RKIP Antibodies.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-RKIP Antibody (77.Ser 153) sc-135778 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
RKIP siRNA (h) sc-36430 10 µM $258
RKIP (h)-PR sc-36430-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
RKIP shRNA Plasmid (h) sc-36430-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
RKIP shRNA (h) Lentiviral Particles sc-36430-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
HL-60 Whole Cell Lysate sc-2209 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PEBP1 5037 12q24.23 P30086
 604591
 

Raf kinase inhibitory protein (RKIP, PEBP) is a modulator of the Raf/MAPK signaling cascade and a suppressor of metastatic cancer. RKIP inhibits MAPK by preventing association of Raf-1 and p21-activated kinase (PAK), and blocking phosphorylation of the Raf-1 kinase domain by PAK and Src kinases. After G protein receptor stimulation, RKIP can dissociate Raf-1 and associate with GRK2, thereby blocking GRK2 activity. This switch is triggered by protein kinase C (PKC)-dependent phosphorylation of the RKIP on Serine 153. RKIP Serine 153 phosphorylation by PKC in response to phorbol ester or epidermal growth factor causes release of RKIP from Raf-1. RKIP antagonizes the signal transduction pathways that mediate the activation of NFkB in response to stimulation with TNF-a or interleukin-1 b.