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p-p53 Antibody (64.Ser 315): sc-135773

 |  Datasheet

(Based on data analysis)
  • p-p53 Antibody (64.Ser 315) is a mouse monoclonal IgG2a provided at 200 µg/ml
  • raised against a short amino acid sequence containing phosphorylated Ser 315 of p53 of human origin
  • recommended for detection of Ser 315 phosphorylated p53 of human origin by WB and ELISA
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-135773 X, 200 µg/0.1 ml
 

See additional p53 Antibodies.

Also see p53 Inhibitors or p53 Activators for functional analysis of cellular responses to p53.


Ordering InformationGene Info
Recommended Support Products:
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WB   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-p53 Antibody (64.Ser 315) sc-135773 200 µg/ml $279
p-p53 Antibody (64.Ser 315) X sc-135773 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p53 siRNA (h) sc-29435 10 µM $258
p53 siRNA (h2) sc-44218 10 µM $258
p53 (h)-PR sc-29435-PR 10 µM, 20 µl $23
p53 (h2)-PR sc-44218-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p53 shRNA Plasmid (h) sc-29435-SH 20 µg $520
p53 shRNA Plasmid (h2) sc-44218-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p53 shRNA (h) Lentiviral Particles sc-29435-V 200 µl $625
p53 shRNA (h2) Lentiviral Particles sc-44218-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
A-431 + EGF Whole Cell Lysate sc-2202 500 µg/200 µl $104
MCF7 + etopside Cell Lysate sc-2281 500 µg/200 µl $104
HeLa + UV Cell Lysate sc-2221 500 µg/200 µl $104
A-431 + PMA Cell Lysate sc-2261 500 µg/200 µl $104
HeLa + hydroxyurea Cell Lysate sc-24682 500 µg/200 µl $104
MCF7 Whole Cell Lysate sc-2206 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human TP53 7157 17p13.1 P04637
 260350
 

p53 is a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor that upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 polyubiquitinates p53 for proteasome targeting. p53 can assemble into tetramers in the absence of DNA, fluctuates between latent and active (DNA-binding) conformations, and is differentially activated through posttranslational modifications including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) (amino acids 110-286) of p53 can compromise energetically favorable association with cis elements and are implicated in several human cancers. Phosphorylation of p53 at residue Thr 155 is mediated by the COP9 signalosome (CSN) and targets p53 to ubiquitin-26S Proteasome-dependent degradation.