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home » Channel Proteins » GABA Receptor Antibody / GABA Receptor Antibodies » p-GABAB R2 (Ser 783): sc-135695

p-GABAB R2 (Ser 783) Antibody: sc-135695

  |  Datasheet
  • rabbit polyclonal IgG, 100µl
  • recommended for detection of Ser 783 phosphorylated GABAB R2 of mouse and rat origin and correspondingly Ser 784 phosphorylated GABAB R2 of human origin by WB, IP and IF; also reactive with additional species, including bovine
 
Additional GABA Receptor Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human GABBR2 9568 9q22.33 O75899
 607340
Mouse Gabbr2 242425 4 B1 Q80T41
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-GABAB R2 (Ser 783) sc-135695 100 µl $279
Lambda Phosphatase sc-200312 100,000 units $462
Lambda Phosphatase sc-200312A 20,000 units $116
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GABAB R2 siRNA (h) sc-42463 10 µM $258
GABAB R2 siRNA (m) sc-42464 10 µM $258
GABAB R2 (h)-PR sc-42463-PR 10 µM $23
GABAB R2 (m)-PR sc-42464-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GABAB R2 shRNA Plasmid (h) sc-42463-SH 20 µg $520
GABAB R2 shRNA Plasmid (m) sc-42464-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GABAB R2 shRNA (h) Lentiviral Particles sc-42463-V 200 µl $625
GABAB R2 shRNA (m) Lentiviral Particles sc-42464-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
rat brain extract sc-2392 500 µg/200 µl $104
mouse brain extract sc-2253 500 µg/200 µl $104

p-GABAB R2 Background Information
GAD-65 and GAD-67, glutamate decarboxylases, catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA (gamma-aminobutyric acid) acts as the main inhibitory transmitter by increasing a Cl-- conductance that inhibits neuronal firing. GABA activates both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Members of the GABAA receptor family include GABAA Rå1-6, GABAA R ∫1-3, GABAA R©1-3, GABAA R∂, GABAA Ré, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1å and GABAB R1∫. PKA phosphorylates GABABR2 at Ser 892. This phosphorylation appears to enhance the membrane stability of GABAB R2. Mouse, rat and human GABAB R2 are phosphorylated on Ser 783 by AMPK∫1, which stabilizes GABAB b activation of inwardly rectifying K+ channels and decreases synaptic activity.

p-GABAB R2 (Ser 783)
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sc-135695
p-GABAB R2 (Ser 783): sc-135695. Western blot analysis of GABAB R2 phosphorylation in untreated (A) and lambda protein phosphatase-treated (B) rat synaptic membrane tissue extracts.
sc-135695
p-GABAB R2 (Ser 783): sc-135695. Western blot analysis of GABAB R2 phosphorylation in 293T whole cell lysate.
sc-135695
p-GABAB R2 (Ser 783): sc-135695. Western blot analysis of GABAB R2 phosphorylation in untreated (A) and lambda protein phosphatase treated (B) mouse brain tissue extracts.
sc-135695
Western blot analysis of GABAB R2 phosphorylation in untreated (A, C) and lambda protein phosphatase treated (B, D) rat brain tissue extracts. Antibodies tested include p-GABAB R2 (Ser 783): sc-135695 (A, B) and GABAB R2 (E-16): sc-22322 (C, D).
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