p-HDAC4/5/9 Antibody | Santa Cruz Biotech

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p-HDAC4/5/9 Antibody : sc-135656	\| Datasheet

5 4 (Based on data analysis) 1

p-HDAC4/5/9 Antibody (Ser 246/259/220) is a rabbit polyclonal IgG provided at 100 µg/ml
recommended for detection of Ser 246 phosphorylated HDAC4 of human origin and correspondingly phosphorylated Ser 245 of mouse origin; Ser 259 phosphorylated HDAC5 of human origin and correspondingly phosphorylated Ser 250 of mouse origin and Ser 200 phosphorylated HDAC9 of human and mouse origin by WB and IP

See additional HDAC Antibodies including HDAC, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, HDAC10 and HDAC11.

Also see HDAC4 Inhibitors for functional analysis of cellular responses to HDAC4 and HDAC5, HDAC9.

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WB IP siRNA

Ordering Information

Product Name	Catalog #	Unit	Price	Qty	Add
p-HDAC4/5/9 Antibody (Ser 246/259/220)	sc-135656	100 µg/ml	$279

Species	Gene Name	Gene ID	Chromosome Location	Protein Accession #	OMIM™ Number

Human	HDAC9	9734	7p21.1	Q9UKV0	606543
Human	HDAC4	9759	2q37.3	P56524	605314
Human	HDAC5	10014	17q21.31	Q9UQL6	605315
Mouse	Hdac5	15184	11 D	Q9Z2V6	N/A
Mouse	Hdac9	79221	12 A3	Q99N13	N/A
Mouse	Hdac4	208727	1 D	Q6NZM9	N/A

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. The histone deacetylases (HDAC) include HDAC1–9. Subject to post-translational modifications, HDAC4, 5 and 9 contain phosphoserine residues at Ser-246, Ser-259 and Ser-220, respectively.

p-HDAC4/5/9 Antibody Data

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p-HDAC4/5/9 (Ser 246/259/220): sc-135656. Western blot analysis of phosphorylated HDAC4/5/9 expression in untreated (A) and Insulin-treated (B) 3T3 cell extracts.

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p-HDAC4/5/9 Antibody : sc-135656