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p-eIF4G (Ser 1232) Antibody: sc-135655 |
| Datasheet |
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- rabbit polyclonal IgG, 100µg/ml
- recommended for detection of Ser 1232 phosphorylated eIF4G of human origin by WB, IP, IF and IHC(P)
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
EIF4G1 |
1981 |
3q27.1 |
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Q04637
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600495 |
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p-eIF4G Background Information
The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex eIF4F exists in vitro as a trimeric complex of eIF4G, eIF4E, and eIF4A. Together, the complex allows ribosome binding to mRNA by inducing the unwinding of mRNA secondary structures (1,2). eIF4E binds to the mRNA “cap” during an early step in the initiation of protein synthesis (3,4). eIF4A acts as an ATP-dependent RNA helicase (5,6). eIF4G acts as a bridge between eIF4E, eIF4A, and the eIF3 complex (7,8). The phosphorylation of human eIF4G is stimulated by Insulin, which targets specific serine resudues, such as Ser 1232, for phosphorylation. |
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p-eIF4G (Ser 1232)
Click on image to enlarge
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p-eIF4G (Ser 1232): sc-135655. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung carcinoma tissue showing cytoplasmic localization.
p-eIF4G (Ser 1232): sc-135655. Western blot analysis of phosphorylated eIF4G expression in untreated (A) and PMA-treated (B) 293 cell extracts.
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