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p-ErbB-3 Antibody (Tyr 1328): sc-135654

 |  Datasheet

(Based on data analysis)

  • p-ErbB-3 Antibody (Tyr 1328) is a rabbit polyclonal IgG provided at 100 µg/ml
  • recommended for detection of Tyr 1328 phosphorylated ErbB-3 of human origin and correspondingly phosphorylated Tyr 1325 of mouse and rat origin by WB, IP, IF and IHC(P)
  • See 1 citations for p-ErbB-3 Antibody (Tyr 1328)
 

See additional ErbB Antibodies including ErbB, ErbB-3 and ErbB-4.

Also see ErbB Inhibitors for functional analysis of cellular responses to ErbB.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   IHC(P)   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-ErbB-3 Antibody (Tyr 1328) sc-135654 100 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
ErbB-3 siRNA (h) sc-35327 10 µM $258
ErbB-3 siRNA (m) sc-35328 10 µM $258
ErbB-3 siRNA (h2) sc-44298 10 µM $258
ErbB-3 (h)-PR sc-35327-PR 10 µM, 20 µl $23
ErbB-3 (m)-PR sc-35328-PR 10 µM, 20 µl $23
ErbB-3 (h2)-PR sc-44298-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
ErbB-3 shRNA Plasmid (h) sc-35327-SH 20 µg $520
ErbB-3 shRNA Plasmid (m) sc-35328-SH 20 µg $520
ErbB-3 shRNA Plasmid (h2) sc-44298-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
ErbB-3 shRNA (h) Lentiviral Particles sc-35327-V 200 µl $625
ErbB-3 shRNA (m) Lentiviral Particles sc-35328-V 200 µl $625
ErbB-3 shRNA (h2) Lentiviral Particles sc-44298-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ERBB3 2065 12q13.2 P21860
 607598
Mouse Erbb3 13867 10 D3 Q61526
 N/A
 

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3. Mouse, rat and human ErbB-3 are subject to phosphorylation on Tyr 1328, an event which is increased by ligand binding.

p-ErbB-3 Antibody (Tyr 1328) Product Citations
See how others have used p-ErbB-3 Antibody (Tyr 1328) and or p-ErbB-3 Antibody (Tyr 1328) conjugates.


1 total citations
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p-ErbB-3 Antibody (Tyr 1328) Data
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sc-135654
p-ErbB-3 (Tyr 1328): sc-135654. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic and membrane localization.
sc-135654
p-ErbB-3 (Tyr 1328): sc-135654. Western blot analysis of phosphorylated ErbB-3 expression in untreated (A) and EGF-treated (B) HUVEC cell extracts.
sc-135654
Western blot analysis of ErbB-3 phosphorylation in untreated (A,D), Neuregulin-1 treated (B,E) and Neuregulin-1 and lambda protein phosphatase (sc-200312A) treated (C,F) T-47D whole cell lysates. Antibodies tested include p-ErbB-3 (Tyr 1328): sc-135654 (A,B,C) and ErbB-3 (5A12): sc-81455 (D,E,F).
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