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p-Tyk 2 Antibody (Tyr 1054): sc-135637

 |  Datasheet

(Based on data analysis)

  • p-Tyk 2 Antibody (Tyr 1054) is a rabbit polyclonal IgG provided at 100 µg/ml
  • raised against a short amino acid sequence containing phosphorylated Tyr 1054 of Tyk 2 of human origin
  • recommended for detection of Tyr 1054 phosphorylated Tyk 2 of human origin and correspondingly phosphorylated Tyr 1047 of mouse origin of mouse and human origin by WB and IP
 

See additional Tyk Antibodies.

Also see Tyk Inhibitors for functional analysis of cellular responses to Tyk.


Ordering InformationGene Info
Recommended Support Products:
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WB   IP   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-Tyk 2 Antibody (Tyr 1054) sc-135637 100 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Tyk 2 siRNA (h) sc-36764 10 µM $258
Tyk 2 siRNA (m) sc-36765 10 µM $258
Tyk 2 (h)-PR sc-36764-PR 10 µM, 20 µl $23
Tyk 2 (m)-PR sc-36765-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Tyk 2 shRNA Plasmid (h) sc-36764-SH 20 µg $520
Tyk 2 shRNA Plasmid (m) sc-36765-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Tyk 2 shRNA (h) Lentiviral Particles sc-36764-V 200 µl $625
Tyk 2 shRNA (m) Lentiviral Particles sc-36765-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human TYK2 7297 19p13.2 P29597
 176941
Mouse Tyk2 54721 9 A3 Q9R117
 N/A
 

Members of the Janus family of tyrosine kinases, including JAK1, JAK2 and Tyk 2, are characterized by the presence of a second kinase domain and the absence of SH2, SH3 and membrane spanning domains. The members of this family of tyrosine kinases play a critical role in coupling ligand binding of cytokine receptors to tyrosine phosphorylation. For instance, Tyk 2 couples IFNa/b binding to tyrosine phosphorylation of the proteins of the IFN-stimulated gene factor 3 complex. The Tyk and Jak family is involved in signal transduction in response to a specific family of cytokines, which consists of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6). Tyk 2 is subject to intermolecular tyrosine phosphorylation after homodimer formation. Human and mouse Tyk 2 are phosphorylated on Tyr 1054, leading Tyk 2 activation.
p-Tyk 2 Antibody (Tyr 1054) Data
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sc-135637
p-Tyk 2 (Tyr 1054): sc-135637. Western blot analysis of phosphorylated Tyk 2 expression in untreated (A) and Anisomycin-treated (B) HT-29 cell extracts.
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