XPG Background Information Seven complementation groups (A-G) of xeroderma pigmentosum have been described. The xeroderma pigmentosum group A protein, XPA, is a zinc metalloprotein which preferentially binds to DNA damaged by ultraviolet (UV) radiation and chemical carcinogens. XPA is a DNA repair enzyme that has been shown to be required for the incision step of nucleotide excision repair. XPG (also designated ERCC5) is an endonuclease that makes the 3’ incision in DNA nucleotide excision repair. Mammalian XPG is similar in sequence to yeast RAD2. Conserved residues in the catalytic center of XPG are important for nuclease activity and function in nucleotide excision repair.
XPG (8H7) Product Citations
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XPG (8H7)
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XPG (8H7) FITC: sc-13563 FITC. Intracellular FCM analysis of fixed and permeabilized UV-irradiated HeLa cells. Black line histogram represents the isotype control, normal mouse IgG2a: sc-2856.
XPG (8H7): sc-13563. Western blot analysis of XPG expression in control (A) and phorbol ester-treated Jurkat (B) nuclear extracts.
XPG (8H7): sc-13563. Western blot analysis of XPG expression in Jurkat nuclear extract.
XPG (8H7): sc-13563. Western blot analysis of XPG expression in Jurkat (A) and K-562 (B) nuclear extracts.
