TLR8 Antibody (9A6): sc-135584

TLR8 Antibody (9A6) is a mouse monoclonal IgG2b kappa light chain antibody that detects TLR8 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-TLR8 antibody (9A6) is available in a non-conjugated form, allowing for versatile applications in research. TLR8, a member of the Toll-like receptor family, plays a crucial role in the innate immune system by recognizing viral RNA and initiating immune responses. TLR8 is primarily located in the endosomal compartments of immune cells, where TLR8 detects pathogens and triggers signaling pathways that lead to the production of pro-inflammatory cytokines. The proper functioning of TLR8 is vital for the host′s defense against viral infections, as TLR8 helps to activate the NFκB signaling pathway, which is essential for mounting an effective immune response. Dysregulation of TLR8 can lead to inadequate immune responses or excessive inflammation, highlighting TLR8′s importance in maintaining immune homeostasis. TLR8 monoclonal antibody (9A6) is an invaluable tool for researchers studying immune responses and the mechanisms of viral recognition.

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TLR8 Antibody (9A6) References:

1. The Relevance of TLR8 in Viral Infections.  |  Martínez-Espinoza, I. and Guerrero-Plata, A. 2022. Pathogens. 11: PMID: 35215078
2. Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis.  |  Peng, C., et al. 2023. J Hypertens. 41: 1245-1257. PMID: 37199563
3. Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice.  |  Maria, NI., et al. 2023. Life Sci Alliance. 6: PMID: 37495396
4. TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis.  |  Kong, X., et al. 2024. Rheumatology (Oxford). 63: 1710-1719. PMID: 37665747
5. TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells.  |  Youness, A., et al. 2023. Biol Sex Differ. 14: 60. PMID: 37723501
6. Safety and efficacy of the oral TLR8 agonist selgantolimod in individuals with chronic hepatitis B under viral suppression.  |  Gane, EJ., et al. 2023. J Hepatol. 78: 513-523. PMID: 38133554
7. MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus.  |  Wang, T., et al. 2024. Cell Commun Signal. 22: 220. PMID: 38589923
8. TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism.  |  Roca Suarez, AA., et al. 2024. Gut. 73: 2012-2022. PMID: 38697771
9. Porcine TLR8 signaling and its anti-infection function are disturbed by immune checkpoint receptor TIM-3 via inhibition of P13K-AKT pathway.  |  Zheng, W., et al. 2024. Int J Biol Macromol. 269: 132018. PMID: 38702002
10. Erythroid-intrinsic activation of TLR8 impairs erythropoiesis in inherited anemia.  |  Liang, J., et al. 2024. Nat Commun. 15: 5678. PMID: 38971858

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TLR8 Antibody (9A6) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-TLR8 Antibody (9A6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TLR8 Antibody (9A6) Specifications

Alternate Product Name: TLR8

Product Clone Name: 9A6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 723-825

Epitope Target: TLR8

Epitope Species: human

Product Reactivity/Detection: TLR8

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for TLR8 Antibody (9A6): N/A

The preferred TLR8 antibody is TLR8 Antibody (D-8): sc-373760.