TIG3 Background Information Retinoids act through ligand-dependent transcription factors, retinoid X receptor (RXRs) and retinoic acid receptors (RARs). Tazarotene-induced gene (TIG) proteins, also designated retinoic acid receptor responder proteins or RAR-responsive proteins, can be membrane bound or secreted. TIGs act as tumor suppressor genes in human cancers and are highly expressed in skin, hair follicles and endothelial cells as well as in pancreas, spleen and intestine. TIGs are activated by tazarotene and have been implicated as growth regulators that mediate the growth suppressive effects of retinoids. TIG1 is a single-pass type II membrane protein activated by tazarotene and RAR proteins. It belongs to the protease inhibitor I47 (latexin) family of proteins. TIG2 is a secreted protein that is mainly expressed in epidermis, hair follicles and endothelial cells. TIG2 is inhibited in psoriatic lesions and is activated by tazarotene in skin rafts and in epidermis of psoriatic lesions. TIG3 is widely expressed in most tissues, but is not detected in heart, testis or brain. TIG3, which is activated by tazarotene, belongs to the H-rev107 family of proteins. TIG3 acts as a growth regulator and is important for mediating the growth suppressive effects of retinoids.
TIG3 (LW-M10)
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TIG3 (LW-M10): sc-135579. Western blot analysis of TIG3 expression in human TIG3 transfected (A) and non-transfected (B) 293T whole cell lysates.
