Nucling (E-12) Antibody: sc-135510

Nucling Background Information
Nucling, also known as UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats) and KIAA1561, is a 1,416 amino acid nuclear and cytoplasmic protein. Up-regulated after TSH-stimulation, Nucling is a component of the apoptosome complex, whose other components include Apaf-1 and caspase-9. Nucling interacts directly with Apaf-1 and regulates it’s redistribution to the nucleus following proapoptotic stress. Nucling also plays a role in the promotion of apoptosis by the galectin-3 down-regulation, apoptosome up-regulation and NF˚B inactivation pathways. Nucling also interacts with ARF6, which may modulate cell shape and motility following injury. Nucling contains six ANK repeats and is expressed highly in kidney, heart, pancreas and skeletal muscle. Nucling is a potential target autoantigen in Behcet disease (BD), Vogt-Koyanagi-Harada (VKH) and sarcoidosis, which cause different types of panuevitis.