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SGLT-6 Antibody (H-40): sc-135408

 |  Datasheet

(Based on data analysis)
  • SGLT-6 Antibody (H-40) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 218-257 mapping within an internal region of SGLT-6 of human origin
  • recommended for detection of SGLT-6 of human origin and Slc5a11 of mouse and rat origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
 
Full-length SGLT-6 protein sequence with immunogen highlighted:
MESGTSSPQPPQLDPLDAFPQKGLEPGDIAVLVLYFLFVLAVGLWSTVKTKRDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSGAATGISVSAYELNGLFSVLMLAWIFLPIYIAGQVTTMPEYLRKRFGGIRIPIILAVLYLFIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIMLIGALTLMGYSFAAVGGMEGLKEKYFLALASNRSENSSCGLPREDAFHIFRDPLTSDLPWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIMVFPGMVSRILFPDQVACADPEICQKICSNPSGCSDIAYPKLVLELLPTGLRGLMMAVMVAALMSSLTSIFNSASTIFTMDLWNHLRPRASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFWGLISGLLLGLVRLVLDFIYVQPRCDQPDERPVLVKSIHYLYFSMILSTVTLITVSTVSWFTEPPSKEMVSHLTWFTRHDPVVQKEQAPPAAPLSLTLSQNGMPEASSSSSVQFEMVQENTSKTHSCDMTPKQSKVVKAILWLCGIQEKGKEELPARAEAIIVSLEENPLVKTLLDVNLIFCVSCAIFIWGYFA

See additional SGLT Antibodies including SGLT-6, SGLT-5, SGLT-4, SGLT-3, SGLT-2, SGLT-1 and SGLT.

Ordering InformationGene Info
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
SGLT-6 Antibody (H-40) sc-135408 200 µg/ml $279
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human SLC5A11 115584 16p12.1 NM_052944 Q8WWX8
 610238
Mouse Slc5a11 233836 7 F3 NM_146198 Q8K0E3
 N/A
 

SGLT-6, also known as SLC5A11 (solute carrier family 5 (sodium/glucose co-transporter), member 11) KST1, SLGTX or SMIT2, is a 675 amino acid multi-pass membrane protein that belongs to the sodium/solute symporter family of transport proteins. Expressed at high levels in kidney, heart, placenta, liver and skeletal muscle, SGLT-6 is involved in the co-transport of Myo-inositol with sodium, specifically facilitating the transport of two Myo-inositols per sodium ion. In addition to its role in sodium transport, SGLT-6 also participates in the transport of glucose and xylose and may function to induce Pdcd-1-dependent cell apoptosis. The gene encoding SGLT-6 is an autoimmune modifier in systemic lupus erythematosus (SLE), suggesting an involvement for SGLT-6 in the pathogenesis of SLE. Multiple isoforms of SGLT-6 exist due to alternative splicing events.