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ACOT7 Antibody (H-300): sc-135339

 |  Datasheet

(Based on data analysis)
  • ACOT7 Antibody (H-300) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 81-380 mapping at the C-terminus of ACOT7 of human origin
  • recommended for detection of ACOT7 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
 
Full-length ACOT7 protein sequence with immunogen highlighted:
MKLLARALRLCEFGRQASSRRLVAGQGCVGPRRGCCAPVQVVGPRADLPPCGACITGRIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRAASAFFTYVSLSQEGRSLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHAEPQP

See additional ACOT Antibodies including ACOT, ACOT1, ACOT2, ACOT4, ACOT6, ACOT7, ACOT8, ACOT9, ACOT10, ACOT11, ACOT3, ACOT5 and ACOT12.

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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
ACOT7 Antibody (H-300) sc-135339 200 µg/ml $279
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ACOT7 11332 1p36.31 NM_007274, NM_181864, NM_181865, NM_181866 O00154
 602587
 

Acyl-CoA thioesterases (ACOTs) are a group of enzymes that catalyze the hydrolysis of acyl-CoA to form coenzyme A (CoA) and a free fatty acid. Through their catalytic activity, ACOTs are able to regulate the level of fatty acids and acyl-CoAs within the cell. ACOT7 (acyl-CoA thioesterase 7), also known as BACH (brain acyl-CoA hydrolase), LACH or CTE-II, is a 380 amino acid protein that is expressed as 6 alternatively spliced isoforms which localize to either the cytoplasm or the mitochondria. Functioning as a homodimer that contains 2 acyl coenzyme A hydrolase domains, ACOT7 plays an important role in regulating acyl-CoA levels within the body and is thought to specifically participate in proper brain physiology and function. Decreased ACOT7 expression may be associated with mesial temporal lobe epilepsy, a form of focal epilepsy that is characterized by simple or complex seizures.
ACOT7 Antibody (H-300) Data
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sc-135339
ACOT7 (H-300): sc-135339. Western blot analysis of ACOT7 expression in Jurkat (A), SK-MEL-28 (B) and U-251 MG (C) whole cell lysates and mouse brain tissue extract (D).
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