VP5 (6F10) Antibody: sc-13525

VP5 Background Information
The viral double-stranded DNA of herpes simplex virus type 1 (HSV-1) is contained inside a large and elaborate icosahedral capsid protein shell and surrounded by a membrane envelope (1). For HSV-1, the outer shell is composed of four proteins: VP5; a small protein bound to hexons, VP26; and a triplex structure made up of heterotrimers of VP19C and VP23 (2). Assembly of the capsomer occurs in the infected-cell nucleus, and the predominant polypetide component of the capsomer is the protein VP5, which is encoded by the gene UL19 (3). VP5 is the structural subunit of both hexons and pentons, which pack together within the intricate lattice of the icosahedral surface (4). VP5 hexons are hexamers of VP5, and these hexons associate with the scaffolding protein VP26 (5). Pentons comprise pentomers of VP5 and are localized at the capsid vertices (6).