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CDD Antibody (FL-146): sc-134754

 |  Datasheet

(Based on data analysis)

  • CDD Antibody (FL-146) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 1-146 representing full length CDD of human origin
  • recommended for detection of CDD (Cytidine deaminase) of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
 
Full-length CDD protein sequence with immunogen highlighted:
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACYPLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKPDGTYIVMTVQELLPSSFGPEDLQKT

See additional CDD Antibodies.

Also see chemical CDD Inhibitors for functional analysis of cellular responses to CDD.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
CDD Antibody (FL-146) sc-134754 200 µg/ml $279
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CDD CRISPR/Cas9 KO Plasmid (h) sc-403915 20 µg $345
CDD HDR Plasmid (h) sc-403915-HDR 20 µg $385
CDD CRISPR/Cas9 KO Plasmid (m) sc-428291 20 µg $345
CDD HDR Plasmid (m) sc-428291-HDR 20 µg $385
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CDD siRNA (h) sc-60341 10 µM $258
CDD siRNA (m) sc-60342 10 µM $258
CDD (h)-PR sc-60341-PR 10 µM, 20 µl $23
CDD (m)-PR sc-60342-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CDD shRNA Plasmid (h) sc-60341-SH 20 µg $520
CDD shRNA Plasmid (m) sc-60342-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CDD shRNA (h) Lentiviral Particles sc-60341-V 200 µl $625
CDD shRNA (m) Lentiviral Particles sc-60342-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HL-60 Whole Cell Lysate sc-2209 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CDA 978 1p36.12 P32320
123920
Mouse Cda 72269 4 D3 P56389
N/A
 


Cytidine deaminase (CDD or CDA) is a member of the cytidine and deoxycytidylate deaminase family of proteins. CDD catalyzes the deamination of chemotherapeutic cytosine nucleoside analogs such as Ara-C and 5-azacytidine, which results in the loss of their cytotoxic and antitumor function. Ara-C is used in the treatment of acute myeloid leukemia (AML), and the antileukemic activity of the drug is contingent on phosphorylation by deoxycytidine kinase (DCK). Resistance to Ara-C is a major determinant of unsucessful AML treatment, the failure of which has been attributed to a DCK functional defect and increased CDD activity. CDD also scavenges endogenous and exogenous cytidine and 2’-deoxycytidine for UMP synthesis. CDD can form homotetramers and is mainly expressed in granulocytes.

CDD Antibody (FL-146) Data
Click on image to enlarge
CDD (FL-146): sc-134754. Western blot analysis of CDD expression in non-transfected 293T: sc-117752 (A), human CDD transfected 293T: sc-116573 (B) and DU 145 (C) whole cell lysates.
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