BLM hydrolase Background Information BLM hydrolase (Bleomycin hydrolase, BLM hydrolase, BMH) is a 455 amino acid protein encoded by the human gene BLMH. BLM hydrolase belongs to the cysteine protease papain superfamily and the peptidase C1 family. It is a cytoplasmic cysteine peptidase commonly found as a homohexamer. It is highly conserved through evolution, however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM). BLM is an essential component of combination chemotherapy regimens for cancer.
BLM hydrolase (6-YD4)
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BLM hydrolase (6-YD4): sc-134283. Western blot analysis of BLM hydrolase expression in non-transfected: sc-117752 (A) and mouse BLM hydrolase transfected: sc-125058 (B) 293T whole cell lysates.
BLM hydrolase (6-YD4): sc-134283. Western blot analysis of BLM hydrolase expression in non-transfected 293T: sc-117752 (A), mouse BLM hydrolase transfected 293T: sc-125060 (B) and WEHI-3 (C) whole cell lysates.
BLM hydrolase (6-YD4): sc-134283. Western blot analysis of BLM hydrolase expression in non-transfected: sc-117752 (A) and mouse BLM hydrolase transfected: sc-125058 (B) 293T whole cell lysates.
BLM hydrolase (6-YD4): sc-134283. Western blot analysis of BLM hydrolase expression in K-562 whole cell lysate.