Exportin 4 (V-18) Antibody: sc-13423

Exportin 4 Background Information
Exportins preferentially bind their substrates at high RanGTP concentrations in the nucleus and then exit the nucleus as trimeric cargo-Exportin-RanGTP complexes. The disassembly of the Exportin-RanGTP complexes involves RanGAP and either RanBP1 or RanBP2, and frees the Exportins for additional nuclear exports. Exportin 1 (soluable cellular export receptor) is a receptor for leucine-rich export sequences and mediates nucleocytoplasmic translocation of Rev-HIV RNA complexes through the nuclear pore. Exportin T binds to functional tRNA and mediates tRNA export from the nucleus. Exportin 4 mediates nuclear export of the eukaryotic translation initiation factor 5A (eIF-5A) by means of a hypusine modification unique to eIF-5A. While a distant member of the importin ∫ superfamily, Exportin 4 shares an N-terminal RanGTP-binding motif with Exportin 1 and Exportin T.