VAMP-5 Background Information The Syntaxin family of proteins anchor themselves to the cytoplasmic surface of cellular membranes and bind to proteins that are involved in exocytosis, including VAMPs (vesicle-associated membrane proteins), NSF (N-ethylmaleimide-sensitive factor), SNAP 25 (synaptosomal-associated protein of 25 kDa), SNAPs (soluble NSF attachment proteins) and synaptotagmin. VAMPs are vesicular factors that are important components of the machinery controlling docking and/or fusion of secretory vesicles. VAMPs are thought to function as inhibitors of exocytosis. VAMP-5 (vesicle-associated membrane protein 5) is a 116 amino acid single-pass type IV membrane protein that belongs to the synaptobrevin family. VAMP-5 may participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or Glut4 trafficking. Containing one v-SNARE coiled-coil homology domain, VAMP-5 localizes to the Golgi apparatus and is encoded by a gene located on human chromosome 2p11.2.
VAMP-5 (O-25)
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VAMP-5 (O-25): sc-134145. Western blot analysis of VAMP-5 expression in human fetal lung tissue extract.
