TSC-22 D2 (K-21) Antibody: sc-134131

TSC-22 D2 Background Information
Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptional regulator to modulate cell growth and differentiation, as well as cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in both the TGF-beta pathway and the PPAR© signaling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, implies an antiproliferative role for TSC-22. TSC-22 D2 (TSC22 domain family protein 2), also known as TILZ4, is a 780 amino acid protein that is related to TSC-22 and is involved in adaptation of renal cells to hypertonicity, suggesting a possible role in signal transduction. Three isoforms exist due to alternative splicing events.