TH-POK Background Information TH-POK (T-helper-inducing POZ/Krueppel-like factor), also known as zinc finger protein 67 (ZFP67), zinc finger and BTB domain-containing protein 7B or krueppel-related zinc finger protein cKrox, is a 539 amino acid protein that contains one BTB (POZ) domain and four C2H2-type zinc fingers. Localized to the nucleus, TH-POK functions primarily as a key regulator of lineage commitment of immature T-cell precursors. Specifically, the presence of TH-POK directs positively selected thymocytes to the CD4 lineage, whereas its absence causes default development to the CD8 lineage. TH-POK also functions as a transcriptional repressor of various other genes, such as COL1A1, COL1A2 and fibronectin.
TH-POK (Y-25)
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TH-POK (Y-25): sc-134085. Western blot analysis of TH-POK expression in HeLa whole cell lysate.
TH-POK (Y-25): sc-134085. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human heart tissue showing cytoplasmic and membrane localization.
TH-POK (Y-25): sc-134085. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tissue showing cytoplasmic and membrane localization.
TH-POK (Y-25): sc-134085. Western blot analysis of TH-POK expression in Hep G2 whole cell lysate.
