TAF II p70 (S-22) Antibody: sc-134051

TAF II p70 Background Information
TFIID is a general transcription factor that facilitates the preinitiation complex assembly through direct interactions with the TATA promoter element. TFIID is a multisubunit complex consisting of a small TATA-binding polypeptide and other TBP-associated factors (TAFs). The TAF II family members include p18, p20, p28, p30, p31, p32, p70, p100, p105, p130, p170 and p250, which is the largest subunit of TFIID. TAF II p70 (TATA-binding protein (TBP) associated factor II70), also known as TAF6, TAF2E, TAFII70, TAFII80 or TAFII85, is a member of the basal transcription complex. TAF II p70 directly interacts with TAF II p31, TAF II p20 and TAF II p250. It forms a heterodimer with TAF II p31 and may function as a p53 coactivator. The TAF II p70/TAF II p31 heterodimer forms a histone-like octamer complex with the TAF II p105/TAF II p20 heterodimer. Several TAF II p70 isoforms exist due to alternative splicing.