SF4 Background Information SF4 (splicing factor 4), also known as RNA-binding protein (RBP) or F23858, is a 645 amino acid nuclear protein and member of the SURP family of splicing factors that is involved in pre-mRNA splicing. Existing as two alternatively spliced isoforms and highly expressed in testis and heart, SF4 is also found in skeletal muscle, brain and kidney where it functions as a component of the spliceosome. SF4 contains two SURP motif repeats, one G-patch domain and is encoded by a gene that maps to human chromosome 19p13.11. Chromosome 19 consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs).
SF4 (B-25)
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SF4 (B-25): sc-133995. Western blot analysis of SF4 expression in Hep G2 whole cell lysate.
