sarcosine dehydrogenase (Z-25) Antibody: sc-133985

sarcosine dehydrogenase Background Information
Sarcosine dehydrogenase, also known as SARDH, SAR, SDH, SARD or DMGDHL1, is a 918 amino acid protein that localizes to the mitochondrial matrix and is involved in the amine and polyamine degradation pathway. Using FAD as a cofactor, sarcosine dehydrogenase catalyzes the oxidative demethylation of sarcosine, a reaction that results in the formation of formaldehyde and glycine from sacrosine. Defects in the gene encoding sarcosine dehydrogenase are associated with sarcosinemia, a relatively benign metabolic disorder characterized by excess sarcosine in plasma and urine. The gene encoding sarcosine dehydrogenase maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome.