OC-3 Background Information OC-3 (One cut domain family member 3) is a 494 amino acid nuclear protein that acts as a transcriptional activator. OC-3 binds the consensus DNA sequence 5’-DHWATTGAYTWWD-3' on a diverse array of gene promoters, such as Prealbumin and HNF-3∫. OC-3 is a member of the ONECUT homeobox family and contains one CUT DNA-binding domain and one homeobox DNA-binding domain. ONECUT proteins regulate gene networks by controlling transcription factor expression and also play an important role in cell metabolism and differentiation. OC-3 shares a significant amount of sequence similarity with OC-1 and OC-2 and is found in upper intestine, stomach and brain in both adult and embryonic mouse. Due to their expression patterns, it is likely that all ONECUT proteins participate in the regulation of organ development from the foregut and midgut endoderm.
OC-3 (W-23)
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OC-3 (W-23): sc-133863. Western blot analysis of OC-3 expression in Hep G2 whole cell lysate.
