OC-2 Background Information The predicted 485 amino acid ONECUT2 (OC-2) protein is a transcriptional activator that functions in activating the transcription of several liver genes, such as HNF3-∫. OC-2 is a member of the CUT homeobox family and contains one CUT DNA-binding domain and one homeobox DNA-binding domain. OC-2 shares several regions of sequence homology with OC-1 (HNF6), including a serine/threonine- and proline-rich sequence (STP box). OC-2 localizes to the nucleus and abundant expression of OC-2 is observed in liver and skin tissues, whereas lower expression is demonstrated in testis, brain (occipital cortex) and urinary bladder tissues. The ability of OC-2 to recognize binding sites present in regulatory regions of liver-expressed genes differ from, but overlap with, those of OC-1. Like OC-1, recombinant OC-2 stimulates transcription of the HNF3-∫ gene. Research also suggests that OC-2 participates in liver differentiation and metabolism.
OC-2 (W-22)
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OC-2 (W-22): sc-133862. Western blot analysis of OC-2 expression in Jurkat whole cell lysate.
