NARG1L Background Information They cytoplasmic protein NARG1 (NMDA (N-methyl-d-aspartate) receptor-regulated gene 1) interacts with ARD1 or ARD2 to form a complex, which exhibits N-terminal (alpha) acetyltransferase activity. This complex interacts with ribosomal subunits functioning in cotranslational acetylation. During apoptosis, both NARG1 and ARD1 are cleaved by caspases, which results in decreased acetyltransferase activity. Knockdown of NARG1 in HeLa cells leads to apoptosis, indicating that properly functioning NARG1 is essential for cell viability. NARG1 is expressed at high levels in dividing tissues such as bone marrow, testis and embryonal brain and it is overexpressed in papillary thyroid carcinomas. The NARG1-like protein (NARG1L) is an 864 amino acid protein that contains 7 TPR repeats and may also be a component of a complex that displays N-terminal acetyltransferase activity.
NARG1L (G-25)
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NARG1L (G-25): sc-133805. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human muscle tissue showing nuclear and cytoplasmic localization.
NARG1L (G-25): sc-133805. Western blot analysis of NARG1L expression in Hep G2 whole cell lysate.
