KCNG1 Background Information
KCNG1 (potassium voltage-gated channel subfamily G member 1) is also known as K13, kH2, KCNG or KV6.1 (voltage-gated potassium channel subunit Kv6.1) and is a multi-pass membrane protein that is 513 amino acids. KCNG1 is expressed as two isoforms and can be obtained from tissues including brain, placenta, kidneys and pancreas. KCNG1 has six transmembrane domains and is localized to the plasma membrane of cells. KCNG1 is an å-subunit that does not form a functional potassium channel unless it is incorporated into a heteromultimer with KV2.1. The KCNG1-KV2.1 heterotetramer is able to form a unique, functional potassium channel. KCNG1 and KV2.1 mRNA colocalize in brain and heart tissues including piriform cortex, hippocampus, dentate gyrus, olfactory tubercle, SA node, atria and ventricle. KCNG1 has an S6 domain regulatory region, followed by a short C-terminal sequence. KCNG1 is thought to regulate KV2.1, and PKA (cAMP-dependent kinase) is thought to regulate KCNG1-KV2.1 structure. Mutations in potassium channel genes are associated with many disorders. However, many pathological situations have only been associated with related chromosomes and have yet to be isolated to specific gene mutations.
