IFIT3 (E-22) Antibody: sc-133687

IFIT3 Background Information
The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. IFIT3 (interferon-induced protein with tetratricopeptide repeats 3), also known as IRG2, IFI60, IFIT4, ISG60 or RIG-G, is a 490 amino acid protein that contains eight TPR repeats and may play a role in cell cycle regulation and cellular proliferation. The gene encoding IFIT3 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.