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- rabbit polyclonal IgG, 100µg/ml
- recommended for detection of HAL of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
HAL |
3034 |
12q23.1 |
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P42357
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609457 |
| Mouse |
Hal |
15109 |
10 C2 |
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P35492
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N/A |
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HAL Background Information
HAL (histidine ammonia-lyase), also known as histidase, HIS or HSTD, is a 657 amino acid protein that belongs to the PAL/histidase family. Considered a cytosolic enzyme, HAL catalyzes the first reaction in histidine catabolism, the non-oxidative deamination of L-histidine to trans-urocanic acid. Urocanic acid is the main ultraviolet (UV) light absorption factor of the stratum corneum of the skin. Defects in the gene encoding HAL causes histidinemia, also referred to as histidinuria. Histidinemia is an autosomal recessive disease characterized by increased levels of histidine, histamine and imidazole in blood, urine and cerebrospinal fluid. Histidinemia also results in decreased levels of the metabolite urocanic acid in blood, urine, and skin cells. Tryptophan and 1-methyltryptophan are strong inhibitors of HAL. |
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HAL (V-21)
Click on image to enlarge
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HAL (V-21): sc-133646. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human muscle tissue showing cytoplasmic localization.
HAL (V-21): sc-133646. Western blot analysis of HAL expression in human fetal liver tissue extract.
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