CD-MPR Background Information CD-MPR (cation-dependent mannose-6-phosphate receptor) is an oligomeric transmembrane protein that plays a critical role in the intracellular delivery of phosphorylated lysosomal enzymes from the trans-Golgi network (TGN). Intracellular trafficking of CD-MPR is mediated by sorting signals in its 67 amino acid cytoplasmic tail, which prevent it from entering the lysosome, where it would be degraded. CD-MPR is predominantly expressed in mouse testicular germ cells and shows differentiated expression during maturation of rat spermatozoa. Increased expression of CD-MPR in Alzheimer’s disease and the location of the CD-MPR gene next to a region on chromosome 12 which is possibly linked to the disease indicate that CD-MPR may play a role in Alzheimer’s disease.
CD-MPR (X-22)
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CD-MPR (X-22): sc-133447. Western blot analysis of CD-MPR expression in Jurkat whole cell lysate.
