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SARA Antibody (F-9): sc-133071

 |  Datasheet

(Based on data analysis)

  • SARA Antibody (F-9) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • raised against amino acids 1-300 of SARA of human origin
  • recommended for detection of SARA of human origin by WB, IP, IF and ELISA
 

See additional SARA Antibodies.

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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
SARA Antibody (F-9) sc-133071 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SARA siRNA (h) sc-36458 10 µM $258
SARA (h)-PR sc-36458-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SARA shRNA Plasmid (h) sc-36458-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SARA shRNA (h) Lentiviral Particles sc-36458-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
Caki-1 Cell Lysate sc-2224 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ZFYVE9 9372 1p32.3 O95405
 603755
 

SARA (NSP, SARA, MADHIP, SMADIP, ZFYVE9, zinc finger FYVE domain containing 9) is a double zinc finger (FYVE domain) protein that influences the recruitment of Smad proteins to the TGF-beta receptor and ensures appropriate subcellular localization of the activated receptor-bound complex. The FYVE domain in SARA directs localization to early endosomal compartments where it can interact with TGF-beta receptors and Smads. Promyelocytic leukemia (PML) tumour suppressor physically interacts with Smad2/3 and SARA and promotes association and accumulation of SARA and TGF-beta receptor in early endosome. SARA can enhance recruitment of protein phosphatase 1 catalytic subunit (PP1c) to Smad7-GADD34 complex by controlling the specific subcellular localization of PP1c. Dephosphorylation of TGF-beta receptor by Smad7 is an effective mechanism for governing negative feedback in TGF-beta signaling.
SARA Antibody (F-9) Data
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sc-133071
SARA (F-9): sc-133071. Western blot analysis of SARA expression in HeLa (A) and Jurkat (B) whole cell lysates.
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