epitope mapping within an internal region of KCNH6 of human origin
recommended for detection of KCNH6 isoforms 1, 2 and 3 of mouse, rat and human origin by WB, IF and ELISA; non cross-reactive with other KCNH family members ; also reactive with additional species, including equine and porcine
KCNH6 Background Information Voltage-gated potassium channels play an essential role in controlling cellular excitability in the nervous system. They regulate a variety of properties including membrane potential as well as the frequency and structure of action potentials. KCNH6, also called potassium voltage-gated channel subfamily H member 6 or human ether-a-go-go potassium channel 2 (hEAG2), is an å subunit of a multi-pass transmembrane potassium channel family. KCNH6 functions in forming the pore of the voltage-gated channel. The channel itself is a homo- or heterotetrameric structure of pore-forming å subunits that associate with modulating ∫ subunits. KCNH6 contains one PAS-associated C-terminal (PAC) domain, one PER-ARNT-SIM (PAS) domain and one cyclic nucleotide-binding domain. Expressed as three isoforms produced by alternative splicing, KCNH6 is present in prolactin-secreting adenomas and throughout the brain.
