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home » Kinases and Phosphatases » GRK Antibody / GRK Antibodies » GRK 2 (C-9): sc-13143

GRK 2 (C-9) Antibody: sc-13143

  |  Datasheet
  • mouse monoclonal IgG2a; 200 µg/ml
  • raised against amino acids 468-689 of GRK 2 of human origin
  • recommended for detection of GRK 2 of mouse, rat and human origin by WB, IP, IF and ELISA
 
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Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ADRBK1 156 11q13.1 NM_001619 P25098
 109635
Mouse Adrbk1 110355 19 A Q99MK8
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
GRK 2 (C-9) sc-13143 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GRK 2 siRNA (h) sc-29337 10 µM $258
GRK 2 siRNA (m) sc-35513 10 µM $258
GRK 2 (h)-PR sc-29337-PR 10 µM $23
GRK 2 (m)-PR sc-35513-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GRK 2 shRNA Plasmid (h) sc-29337-SH 20 µg $520
GRK 2 shRNA Plasmid (m) sc-35513-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
GRK 2 shRNA (h) Lentiviral Particles sc-29337-V 200 µl $625
GRK 2 shRNA (m) Lentiviral Particles sc-35513-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Ramos Cell Lysate sc-2216 500 µg/200 µl $104
HL-60 Whole Cell Lysate sc-2209 500 µg/200 µl $104
RAW 264.7 Whole Cell Lysate sc-2211 500 µg/200 µl $104
PC-12 Cell Lysate sc-2250 500 µg/200 µl $104
PC-3 Cell Lysate sc-2220 500 µg/200 µl $104
GRK 2 (m): 293T Lysate sc-120637 100µg/200µl $205
GRK 2 (h): 293T Lysate sc-111619 100µg/200µl $205
NAMALWA Cell Lysate sc-2234 500 µg/200 µl $104

GRK 2 Background Information
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of ∫-adrenergic receptor kinase: GRK 2 (∫ARK, ∫ARK1) and GRK 3 (∫ARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

GRK 2 (C-9) Product Citations
See how others have used GRK 2 (C-9): sc-13143 antibody and or GRK 2 (C-9) antibody conjugates.


9 total citations
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GRK 2 (C-9)
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sc-13143
GRK 2 (C-9): sc-13143. Immunofluorescence staining of methanol-fixed RAW 264.7 cells showing cytoplasmic and membrane staining.
sc-13143
GRK 2 (C-9): sc-13143. Western blot analysis of GRK 2 expression in Ramos (A), RAW 264.7 (B) and PC-12 (C) whole cell lysates.
sc-13143
GRK 2 (C-9): sc-13143. Western blot analysis of GRK 2 expression in HL-60 (A), PC-3 (B), RAW 264.7 (C) and NAMALWA (D) whole cell lysates.
sc-13143
GRK 2 (C-9): sc-13143. Western blot analysis of GRK 2 expression in non-transfected 293T: sc-117752 (A), human GRK 2 transfected 293T: sc-115352 (B) and A-431 (C) whole cell lysates.
sc-13143
GRK 2 (C-9): sc-13143. Western blot analysis of GRK 2 expression in non-transfected: sc-117752 (A) and human GRK 2 transfected: sc-111619 (B) 293T whole cell lysates.
sc-13143
GRK 2 (C-9): sc-13143. Western blot analysis of GRK 2 expression in non-transfected 293T: sc-117752 (A), human GRK 2 transfected 293T: sc-172730 (B) and BJAB (C) whole cell lysates.
sc-13143
GRK 2 (C-9): sc-13143. Western blot analysis of GRK 2 expression in non-transfected 293T: sc-117752 (A), mouse GRK 2 transfected 293T: sc-120637 (B) and BJAB (C) whole cell lysates.
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