Moesin Antibody (E-10): sc-13122

Moesin Antibody (E-10) is a mouse monoclonal IgM kappa light chain antibody that detects Moesin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Moesin antibody (E-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Moesin, along with Ezrin and Radixin, is part of a family of highly homologous actin-associated proteins that are localized just beneath the plasma membrane, playing a crucial role in linking the cytoskeleton to the plasma membrane. This interaction is vital for maintaining cell shape, facilitating cell signaling, and promoting cellular motility, which are essential processes in development and tissue repair. Notably, Moesin is involved in the regulation of cell adhesion and migration, making Moesin a key player in various physiological and pathological processes, including cancer metastasis. The distinct receptor-specific pattern of phosphorylation exhibited by Moesin, Ezrin, and Radixin, despite their high homology, underscores the complexity of their regulatory mechanisms and their specific roles in cellular functions.

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Moesin Antibody (E-10) References:

1. A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites.  |  Sato, N., et al. 1992. J Cell Sci. 103 (Pt 1): 131-43. PMID: 1429901
2. Moesin: a member of the protein 4.1-talin-ezrin family of proteins.  |  Lankes, WT. and Furthmayr, H. 1991. Proc Natl Acad Sci U S A. 88: 8297-301. PMID: 1924289
3. cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1.  |  Gould, KL., et al. 1989. EMBO J. 8: 4133-42. PMID: 2591371
4. Suppression of breast cancer-associated bone loss with osteoblast proteomes via Hsp90ab1/moesin-mediated inhibition of TGFβ/FN1/CD44 signaling.  |  Sun, X., et al. 2022. Theranostics. 12: 929-943. PMID: 34976221
5. Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells.  |  Gu, J., et al. 2022. Cell Rep. 39: 110986. PMID: 35732125
6. M2 exosomes modified by hydrogen sulfide promoted bone regeneration by moesin mediated endocytosis.  |  Zhou, YK., et al. 2024. Bioact Mater. 31: 192-205. PMID: 37593496
7. FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis.  |  Barik, GK., et al. 2023. Cell Death Dis. 14: 623. PMID: 37736741
8. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.  |  Tsukita, S., et al. 1994. J Cell Biol. 126: 391-401. PMID: 7518464
9. Ezrin has properties to self-associate at the plasma membrane.  |  Andréoli, C., et al. 1994. J Cell Sci. 107 (Pt 9): 2509-21. PMID: 7844168
10. Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker.  |  Algrain, M., et al. 1993. J Cell Biol. 120: 129-39. PMID: 8416983
11. The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation.  |  Fazioli, F., et al. 1993. Oncogene. 8: 1335-45. PMID: 8479753
12. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein.  |  Dransfield, DT., et al. 1997. EMBO J. 16: 35-43. PMID: 9009265

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Moesin Antibody (E-10) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-Moesin Antibody (E-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Moesin Antibody (E-10) Specifications

Alternate Product Name: Moesin

Product Clone Name: E-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 512-526

Epitope Target: Moesin

Epitope Species: human

Product Reactivity/Detection: Moesin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for Moesin Antibody (E-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF647: Alexa Fluor^® 647, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Ezrin antibody is Ezrin Antibody (3C12): sc-58758.